PHYSICAL THERAPY IN THE REHABILITATION OF PATIENTS FOLLOWING BREAST CANCER TREATMENT (LITERATURE REVIEW)
DOI:
https://doi.org/10.32782/2522-1795.2025.19.1.1Keywords:
breast cancer, rehabilitation, physical therapy, quality of lifeAbstract
This article summarizes the current challenges, issues, and selected modern approaches to physical therapy in the rehabilitation of patients who have undergone specialized treatment for breast cancer (BC). BC is the most common malignant neoplasm (MN) among the female population worldwide, with approximately 2.296.840 new cases recorded in 2022. However, the implementation of breast cancer screening and improvements in diagnostic and therapeutic interventions have led to significantly high survival rates, with a five-year survival rate of approximately 81% in Europe. Despite these advancements, many breast cancer survivors experience a range of neuromuscular, musculoskeletal, pain-related, and functional disorders resulting from both the disease and its treatment. These challenges underscore the growing importance of rehabilitation measures to enhance quality of life and, to some extent, improve overall prognosis. The aim of this study was to examine, analyze, and summarize the current challenges and contemporary approaches to physical therapy in the rehabilitation of patients who have received specialized treatment for breast cancer. Methods. A search for relevant sources was conducted in the following databases: PubMed, Medline, Cochrane Library, Embase, BMJ Group, and Google Scholar. Results. Several barriers hinder the effective implementation of rehabilitation measures, including a lack of knowledge, limited access to care, and poor adherence to treatment regimens. A substantial body of evidence supports the benefits of incorporating range-of-motion exercises, aerobic activities, resistance training, and stretching, which have been shown to improve shoulder mobility and reduce pain without increasing the risk of lymphedema development or progression. Additionally, combined physical therapy interventions have demonstrated effectiveness in reducing upper limb swelling. Conclusion. The integration of physical rehabilitation programs into the clinical management of breast cancer patients is a crucial step toward ensuring optimal conditions for achieving maximum independence and the best possible quality of life. A multidisciplinary approach is essential to address the oncological, functional, and psychosocial needs of this patient cohort.
References
1. Бюлетень національного канцер-реєстру України № 24 «Рак в Україні», 2021–2022. / З.П. Федоренко, О.В. Сумкіна, В.О. Зуб та ін. Національний інститут раку. Київ, 2023. 148 с.
2. Abedi G., Janbabai G., Moosazadeh M., Farshidi F., Amiri M., Khosravi A. Survival Rate of Breast Cancer in Iran: A Meta-Analysis. Asian Pac J Cancer Prev. 2016;17(10):4615–4621. doi: 10.22034/apjcp.2016.17.10.4615.
3. Abdullah N.A., Wan Mahiyuddin W.R., Muhammad N.A., et al. Survival rate of breast cancer patients in Malaysia: a populationbased study. Asian Pac J Cancer Prev. 2013;14(8):4591–4594. doi: 10.7314/apjcp.2013.14.8.4591.
4. Allemani C., Sant M., Weir H.K., et al. Breast cancer survival in the US and Europe: a CONCORD high-resolution study. Int J Cancer. 2013;132(5):1170–1181. doi: 10.1002/ijc.27725.
5. Brouwers M.C., Kho M.E., Browman G.P., et al. AGREE II: advancing guideline development, reporting and evaluation in health care. CMAJ. 2010;182(18):E839–E842. doi: 10.1503/cmaj.090449.
6. Casla S., López-Tarruella S., Jerez Y., et al. Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial. Breast Cancer Res Treat. 2015;153(2):371–382. doi: 10.1007/s10549-015-3541-x.
7. Cheema B.S., Kilbreath S.L., Fahey P.P., Delaney G.P., Atlantis E. Safety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2014;148(2):249–268. doi: 10.1007/s10549-014-3162-9.
8. Cheville A.L., Troxel A.B., Basford J.R., Kornblith A.B. Prevalence and treatment patterns of physical impairments in patients with metastatic breast cancer. J Clin Oncol. 2008;26(16):2621–2629. doi: 10.1200/JCO.2007.12.3075.
9. Cho Y., Do J., Jung S., Kwon O., Jeon J.Y. Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection. Support Care Cancer. 2016;24(5):2047–2057. doi: 10.1007/s00520-015-3005-1.
10. Buonomo O.C., Grasso A., Pistolese C.A., Anemona L., Portarena I., Meucci R., Morando L., Deiana C., Materazzo M., Vanni G. Evaluation of Concordance Between Histopathological, Radiological and Biomolecular Variables in Breast Cancer Neoadjuvant Treatment. Anticancer Res. 2020; 40: 281–286.
11. Falcicchio C., Di Lallo D., Fabi A., et al. Use of rehabilitation pathways in women with breast cancer in the first 12 months of the disease: a retrospective study. BMC Cancer. 2021;21(1):311. doi: 10.1186/s12885-021-07927-0.
12. Földi E., Földi M., Clodius L. The lymphedema chaos: a lancet. Ann Plast Surg. 1989;22(6):505–515. doi: 10.1097/00000637-198906000-00007.
13. Ganz P.A. Current issues in cancer rehabilitation. Cancer. 1990;65(3 Suppl):742–751. doi: 10.1002/1097-0142 ( 1 9 9 0 0 2 0 1 ) 6 5 : 3 + < 7 4 2 : : a i d - cncr2820651319>3.0.co;2-p.
14. De Groef A., Van Kampen M., Dieltjens E., et al. Effectiveness of postoperative physical therapy for upper-limb impairments after breast cancer treatment: a systematic review. Arch Phys Med Rehabil. 2015;96(6):1140–1153. doi: 10.1016/j.apmr.2015.01.006.
15. Globocan 2022. URL: http://gco.iarc.fr/.
16. Harris S.R., Schmitz K.H., Campbell K.L., McNeely M.L. Clinical practice guidelines for breast cancer rehabilitation: syntheses of guideline recommendations and qualitative appraisals. Cancer. 2012;118(8 Suppl):2312–2324. doi: 10.1002/cncr.27461.
17. Hidding J.T., Beurskens C.H., van der Wees P.J., van Laarhoven H.W., Nijhuis-van der Sanden M.W. Treatment related impairments in arm and shoulder in patients with breast cancer: a systematic review. PLoS One. 2014;9(5):e96748. doi: 10.1371/journal.pone.0096748.
18. Lan N.H., Laohasiriwong W., Stewart J.F. Survival probability and prognostic factors for breast cancer patients in Vietnam. Glob Health Action. 2013;6:1–9. Published 2013 Jan 17. doi: 10.3402/gha.v6i0.18860.
19. McNeely M.L., Campbell K., Ospina M., et al. Exercise interventions for upperlimb dysfunction due to breast cancer treatment. Cochrane Database Syst Rev. 2010;(6):CD005211. doi: 10.1002/14651858.CD005211.pub2.
20. Sinaga E.S., Ahmad R.A., Shivalli S., Hutajulu S.H. Age at diagnosis predicted survival outcome of female patients with breast cancer at a tertiary hospital in Yogyakarta, Indonesia. Pan Afr Med J. 2018;31:163. doi: 10.11604/pamj.2018.31.163.17284.
21. Smith-Turchyn J., Richardson J., Tozer R., McNeely M., Thabane L. Physical Activity and Breast Cancer: A Qualitative Study on the Barriers to and Facilitators of Exercise Promotion from the Perspective of Health Care Professionals. Physiother Can. 2016;68(4):383–390. doi: 10.3138/ptc.2015-84.
22. Spence R.R., Heesch K.C., Brown W.J. Exercise and cancer rehabilitation: a systematic review. Cancer Treat Rev. 2010;36(2):185–194. doi: 10.1016/j.ctrv.2009.11.003.
23. Stubblefield M.D. The Underutilization of Rehabilitation to Treat Physical Impairments in Breast Cancer Survivors. PM R. 2017;9(9S2):S317–S323. doi: 10.1016/j.pmrj.2017.05.010.
24. Stubblefield M.D., Keole N. Upper body pain and functional disorders in patients with breast cancer. PM R. 2014;6(2):170–183. doi: 10.1016/j.pmrj.2013.08.605.
25. Dimitrov G., Atanasova M., Popova Y., Vasileva K., Milusheva Y., Troianova P. Molecular and genetic subtyping of breast cancer: the era of precision oncology. WCRJ .2022; 9: e2367.
26. Vella F., Senza P., Vitale E., Marconi A., Rapisarda L., Matera S., Cannizzaro E., Rapisarda V. Work ability in healthcare workers (HCWs) after breast cancer: preliminary data of a pilot study. WCRJ. 2021; 8: e1840.
27. Berretta M., Facchini B.A., Garozzo D., Necci V., Taibi R., Torrisi C., Ficarra G. and Bitto A. Adapted physical activity for breast cancer patients: shared considerations with two Olympic and world Italian sports champions. Eur Rev Med Pharmacol Sci. 2022; 26: 5393–5398.
28. Esteva F.J., Hubbard-Lucey V.M., Tang J., and Pusztai L. Immunotherapy and targeted therapy combinations in metastatic breast cancer. Lancet. Oncol. 2019. 20 (3), e175–e186. doi: 10.1016/s1470-2045(19)30026-9.
29. Invernizzi M., Lopez G., Michelotti A., Venetis K., Sajjadi E., De Mattos-Arruda L., et al. Integrating biological advances into the clinical management of breast cancer related lymphedema. Front. Oncol. 2020. 10, 422. doi: 10.3389/fonc.2020.00422.
30. Pierce B.L., Ballard-Barbash R., Bernstein L., Baumgartner R.N., Neuhouser M.L., Wener M.H., et al. Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J. Clin. Oncol. 2009. 27 (21), 3437–3444. doi: 10.1200/jco.2008.18.9068.
31. Mancuso P. The role of adipokines in chronic inflammation. Immunotargets Ther. 2016. 5, 47–56. doi:10.2147/itt.s73223.
32. Upadhyay S., Sharma N., Gupta K.B., and Dhiman M. Role of immune system in tumor progression and carcinogenesis. J. Cell. Biochem. 2018. 119 (7), 5028–5042. doi: 10.1002/jcb.26663.
33. Liu H., Yang Z., Lu W., Chen Z., Chen L., Han S., et al. Chemokines and chemokine receptors: A new strategy for breast cancer therapy. Cancer Med. 2020. 9 (11), 3786–3799. doi:1 0.1002/cam4.3014.
34. Bartlett D.B., Hanson E.D., Lee J.T., Wagoner C.W., Harrell E.P., Sullivan S.A., et al. The effects of 16 Weeks of exercise training on Neutrophil functions in breast cancer survivors. Front. Immunol. 2021. 12, 733101. doi: 10.3389/fimmu.2021.733101.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.